Dihydrofolate reductase inhibitory potential of 1H-indole-based-meldrum linked 1H-1,2,3-triazoles as new anticancer derivatives: In-vitro and in-silico studies.

In this present work, we describe the syntheses of a new series of 32 1H-indole-based-meldrum linked 1H-1,2,3-triazole derivatives (2-13, 15a-15f, 16a-16f, 17a-17f and 19a, 19b, 20a), which constitute a new class of 1H-1,2,3-triazoles. Compounds 15a-15f, 16a-16f, 17a-17f have been prepared by employing "click" reactions between substituted 1H-indole-based meldrum alkynes (11, 12 and 13) and substituted aromatic azides (14a-14f) in the presence of copper iodide (CuI) and Hünig's base. Then, the synthesis of compounds 19, 20 through decomposition of meldrum moiety.

Conventional medication adherence and self-treatment practices among South Asian immigrants: a qualitative study.

Introduction Globally, cardiovascular disease (CVD) is a common cause of death. The highest CVD rate is among South Asian populations and South Asian immigrants have a higher risk of developing CVD than other ethnic groups. While treatment of established CVD risk factors is recommended, medication adherence may be poor.

Elsberg syndrome - A systematic review of existing scientific literature from 2000 - 2023.

Objective: To assess the clinical presentation, causative agents, and treatment outcomes in patients diagnosed with Elsberg syndrome (ES).

Methods: A thorough literature search was conducted on the mentioned topic using PRISMA guidelines via PubMed, Google Scholar, and SCOPUS. Articles published between 2000 and 2023 were included using advanced search and Boolean strategy.

Forced one-dimensional swarmalator model.

We study a simple model of swarmalators subject to periodic forcing and confined to moving around a one-dimensional ring. This is a toy model for physical systems with a mix of sync, swarming, and forcing, such as colloidal micromotors. We find rich behavior: pinned states where the swarmalators are locked to the driving, sync states where their phases are either identical or have fixed differences, and unsteady states, such as swarmalator chimera where the population splits into two sync dots enclosed by a "train" of swarmalators that run around a peanut-shaped loop.