Publications by authors named "M Akcelik"

It is well-established that the dam and seqA genes act in the biofilm production in Salmonella. However, the molecular basis underlying this activity remains unexplored. This study aims to address this gap in the literature.

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Article Synopsis
  • Dysbiosis in gut microbiota, linked to infections, may be significantly influenced by the Typhimurium 14028 WT strain.
  • The study investigates how this strain affects rat gut microbiota and the roles of specific genes in inducing dysbiosis.
  • Results indicate that infection with Typhimurium alters microbiota composition, reduces diversity and richness, and promotes opportunistic pathogens.
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In recent years, as the paradigm of communication between cells has been clarified, the ability of bacteria to change their gene expression patterns in response to various extracellular signals has attracted great interest. In particular, intracellular and intercellular communication between bacterial populations, called quorum sensing (QS), is essential for coordinating physiological and genetic activities. QS studies are critical, particularly in elucidating the regulatory mechanisms of infectious processes in food-borne pathogens.

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Salmonella is a prevalent foodborne pathogen causing millions of global cases annually. Antimicrobial resistance is a growing public health concern, leading to search for alternatives like bacteriophages. A total of 97 bacteriophages, isolated from cattle farms (n = 48), poultry farms (n = 37), and wastewater (n = 5) samples in Türkiye, were subjected to host-range analysis using 36 Salmonella isolates with 18 different serotypes.

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Purpose: To examine the biofilm formation characteristics of bacteria identified at the genus level in samples obtained from silicone tubes after dacryocystorhinostomy surgery.

Methods: In the study involving consecutive patients who underwent dacryocystorhinostomy surgery at Ankara Bilkent City Hospital and whose silicone tubes were removed six months after surgery, between January 2023 and May 2023; the tubes were placed in glycerol-PBS (phosphate buffered saline) solution and cultured on descriptive selective media at the genus level. The biofilm-forming properties of the obtained isolates were examined in solid-air and liquid-air interphases.

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