Publications by authors named "M Ainouze"
Article Synopsis
- NK cells often lose their function during tumor development, but the reasons for this are not fully understood.
- In mouse lymphoma models, the activation of NK cells led to changes resembling T cell exhaustion, including the expression of immune checkpoint proteins, but dysfunction occurred only in the activated NK cell group.
- Importantly, NK cell dysfunction can be reversed by stopping the stimulation and is positively influenced by interleukin-15, indicating that the dysfunction is a dynamic and reversible process not directly linked to immune checkpoint protein expression.
Article Synopsis
- Autosomal recessive PRKCD deficiency is linked to systemic lupus erythematosus, but its specific mechanisms are not well understood.
- Researchers created a mouse model with the Prkcd G510S mutation to study the disease, which mimics human symptoms and shows a shortened lifespan.
- The study found that this mutation affects B cell activation through the PI3K/mTOR pathway, leading to autoimmune symptoms that improve with rapamycin treatment, highlighting the pathway's role in PRKCD-related autoimmunity and reduced NK cell levels contributing to viral infection susceptibility.
Article Synopsis
- Juvenile idiopathic arthritis (JIA) is the most prevalent chronic rheumatic disease in children, and the underlying causes are still not well understood, particularly in cases with genetic factors like LACC1 mutations.
- This study investigated four families with early-onset arthritis and identified that mutations in LACC1 lead to deficiencies in macrophage autophagy, a crucial cellular process.
- The findings suggest that LACC1 plays a significant role in macrophage energy metabolism and could be linked to a new genetic type of juvenile arthritis due to its impact on autophagy functions.
Antiviral effectors such as natural killer (NK) cells have impaired functions in chronic hepatitis B (CHB) patients. The molecular mechanism responsible for this dysfunction remains poorly characterised. We show that decreased cytokine production capacity of peripheral NK cells from CHB patients was associated with reduced expression of NKp30 and CD16, and defective mTOR pathway activity.
View Article and Find Full Text PDFEffective B cell responses such as cytokine secretion, proliferation, and Ab-specific responses are essential to clear hepatitis B virus (HBV) infection. However, HBV alters numerous immune pathways to persist in the host. B cell activity depends on activation of the innate sensor TLR9 by viral or bacterial DNA motifs.
View Article and Find Full Text PDF