Publications by authors named "M Agustina Chaplin"
Insomnia is a common and challenging complaint in older adults (> 65 years) because of age-related alterations in sleep physiology. Cognitive behavioral therapy for insomnia is the gold standard for treatment of insomnia in young as well as older patients. Both clinicians and patients often prefer the simplicity of medication, but risks associated with some hypnotics increase with age.
View Article and Find Full Text PDFRationale: Postpartum haemorrhage (PPH), defined as a blood loss of 500 mL or more within 24 hours of birth, is the leading global cause of maternal morbidity and mortality. Allogenic blood transfusions are a critical component of PPH management, yet are often unfeasible, particularly in resource-poor settings where maternal morbidity is highest. Autologous cell salvage in the management of PPH has been proposed to combat limitations in access to allogenic blood and potential transfusion-related risks.
View Article and Find Full Text PDFArticle Synopsis
- The protocol outlines a Cochrane Review aimed at evaluating the effectiveness of vaccines for preventing Ebola virus disease.
- The primary focus is on individuals who have been directly exposed or may have been exposed to the Ebola virus.
- The review will analyze existing studies to determine how well these vaccines perform in preventing the disease in those at risk.
Article Synopsis
- Renal cell carcinoma is the most prevalent kidney cancer, representing about 85% of renal cancers, with patients categorized based on their risk for disease progression.
- The objective of the appraisal was to evaluate the effectiveness and cost-effectiveness of the drug combination lenvatinib plus pembrolizumab compared to other approved treatments such as sunitinib and nivolumab plus ipilimumab.
- The assessment relied on systematic reviews and meta-analyses, specifically analyzing data from the CLEAR trial, which supported the efficacy and safety of lenvatinib combined with pembrolizumab over sunitinib.
Despite the critical importance of virus disinfection by chlorine, our fundamental understanding of the relative susceptibility of different viruses to chlorine and robust quantitative relationships between virus disinfection rate constants and environmental parameters remains limited. We conducted a systematic review of virus inactivation by free chlorine and used the resulting data set to develop a linear mixed model that estimates chlorine inactivation rate constants for viruses based on experimental conditions. 570 data points were collected in our systematic review, representing 82 viruses over a broad range of environmental conditions.
View Article and Find Full Text PDF