Publications by authors named "M Aggarwal"
Importance: During the 2023-2024 respiratory syncytial virus (RSV) season in the United States, 2 new RSV prevention products were recommended to protect infants in their first RSV season: nirsevimab and Pfizer's maternal RSV vaccine. Postlicensure studies are needed to assess prevention product impact and effectiveness.
Objective: To compare the epidemiology and disease burden of medically attended RSV-associated acute respiratory illness (ARI) among children younger than 5 years during the 2023-2024 RSV season with 3 prepandemic RSV seasons (2017-2020), estimate nirsevimab effectiveness against medically attended RSV-associated ARI, and compare nirsevimab binding site mutations among circulating RSV in infants with and without nirsevimab receipt.
Background: Impaired pulmonary function carries significant risks for lung, cardiovascular, and metabolic disorders.
Research Question: Can circulating protein biomarkers of pulmonary function provide insight into the pathophysiologic features of lung function impairment and links to comorbidities?.
Study Design And Methods: We analyzed plasma levels of 2,922 proteins in 32,493 UK Biobank participants (53% female; mean [SD] age, 57 [8] years) to investigate their associations with spirometry measures of lung function (FEV, FVC, FEV to FVC ratio), and with obstructive (n = 4,713) and restrictive (n = 3,886) spirometry patterns.
Article Synopsis
- A systematic study has been conducted on how nuclear deformation affects the half-lives of proton decay in nuclei with atomic number Z<82, examining the relationship between 1p-decay half-lives and the shapes of both parent and daughter nuclei.
- The research incorporates the nuclear deformations of the emitters and residues to create a new semi-empirical formula that accurately estimates 1p-decay half-lives, reliably predicting measured values and aiding in forecasting other potential proton emitters.
- The phenomenon of shape coexistence in proton emitters and their daughter nuclei introduces additional factors affecting half-life estimations, as it creates secondary minima in potential energy surfaces and adds new decay pathways