Effect of pre- and postnatal manganese exposure on brain histamine content in a rodent model of Parkinson's disease.

Rats lesioned shortly after birth with 6-hydroxydopamine (6-OHDA; 134 μg icv) represent a near-ideal model of severe Parkinson's disease because of the near-total destruction of nigrostriatal dopaminergic fibers. There are scarce data that in Parkinson's disease, activity of the central histaminergic system is increased. The element manganese, an essential cofactor for many enzymatic reactions, itself in toxic amount, replicates some clinical features similar to those of Parkinson's disease.

Ontogenetic exposure of rats to pre- and post-natal manganese enhances behavioral impairments produced by perinatal 6-hydroxydopamine.

Rats lesioned shortly after birth with 6-hydroxydopamine (6-OHDA; 134 μg icv) represent a near-ideal model of severe Parkinson's disease because of the near-total destruction of nigrostriatal dopaminergic fibers. The element manganese, an essential cofactor for many enzymatic reactions, itself in toxic amount, replicates some clinical features similar to those of Parkinson's disease. The aim of this study was to examine the effect of neonatal manganese exposure on 6-OHDA modeling of Parkinson's disease in rats.

The influence of carbon fibres on the resorption time and mechanical properties of the lactide-glycolide co-polymer.

In this study the influence of short carbon fibres (CF) on mechanical properties and degradation time of the lactide-glycolide co-polymer (PGLA) and on the mechanism of bone ingrowth into the implants was determined. Mechanical properties and push-out tests were measured. The pH of solutions and the implants' weights were tested after incubation in Ringer fluid.

[Diagnosis and treatment of zygomatic bone fractures].

Zygomatic bone fractures are the second most often injury of facial skeleton and sometimes cause diagnostic and treatment problems. Authors of this article present diagnostic and treatment methods applied in 165 patients (139 men, 22 women, 4 children) treated in I Department of Maxillofacial Surgery in Zabrze, in year 1996-2000. Closed repositioning was performed in 70 patients with fractures with single bone fragment.