Purpose: To reduce breast tumor size before surgery, Neoadjuvant Chemotherapy (NAC) is applied systematically to patients with local breast cancer. However, with the existing clinical protocols, it is not yet possible to have an early prediction of the effect of chemotherapy on a breast tumor. Predicting the response to chemotherapy could reduce toxicity and delay effective treatment.
View Article and Find Full Text PDFInt J Comput Assist Radiol Surg
September 2020
Purpose: Neoadjuvant chemotherapy (NAC) aims to minimize the tumor size before surgery. Predicting response to NAC could reduce toxicity and delays to effective intervention. Computational analysis of dynamic contrast-enhanced magnetic resonance images (DCE-MRI) through deep convolution neural network (CNN) has shown a significant performance to distinguish responders and no responder's patients.
View Article and Find Full Text PDFBackground: Early prediction of nonresponse is essential in order to avoid inefficient treatments.
Purpose: To evaluate if parametrical response mapping (PRM)-derived biomarkers could predict early morphological response (EMR) and pathological complete response (pCR) 24-72 hours after initiation of chemotherapy treatment and whether concentric analysis of nonresponding PRM regions could better predict response.
Study Type: This was a retrospective analysis of prospectively acquired cohort, nonrandomized, monocentric, diagnostic study.
Int J Comput Assist Radiol Surg
August 2018
Purpose: This study aims to provide and optimize a performing algorithm for predicting the breast cancer response rate to the first round of chemotherapy using Magnetic Resonance Imaging (MRI). This provides an early recognition of breast tumor reaction to chemotherapy by using the Parametric Response Map (PRM) method.
Methods: PRM may predict the breast cancer response to chemotherapy by analyzing voxel-by-voxel temporal intra-tumor changes during one round of chemotherapy.