Publications by authors named "M Adolfina Ruiz"
We describe a patient with sickle cell disease (SCD) and elevated antiphospholipid antibodies (aPL) who developed multi-organ failure resembling catastrophic antiphospholipid syndrome. Autoimmune screening revealed several autoantibodies characteristic of systemic lupus erythematosus (SLE). Notably, routinely housed and unmanipulated transgenic sickle mice displayed significantly elevated titres of aPL- and SLE-associated autoantibodies.
View Article and Find Full Text PDFPurpose: The aim of the study was to examine the relationship between dispositional mindfulness, cognitive appraisals, emotions, and psychobiosocial experiences in athletes within the framework of multi-states (MuSt) theory.
Method: A convenience sample of 334 Italian athletes (188 men and 146 women), aged 18-48 years ( = 24.77, = 7.
Article Synopsis
- Social rejection is linked to negative health effects, but its impact on decision-making is less understood, especially in the context of social media.
- The study investigated how experiences of acceptance and rejection influenced participants' choices, revealing that after rejection, individuals were more inclined to make their own decisions unless they felt particularly negative afterward.
- Additionally, feelings of negativity affected participants' willingness to engage socially in the future, and individual differences like social anxiety played a role in how they made choices.
Self-confidence, mental toughness, and psychobiosocial experiences in elite rugby players.
Psychol Sport Exerc
December 2024
Article Synopsis
- The study explored how self-confidence, mental toughness, coping strategies, and appraisals of challenges or threats affect athletes' psychological and social experiences, using multi-states (MuSt) theory as a framework.
- Researchers assessed 76 elite male rugby players from the Italian national team during their training for the 2024 Men's Six Nations Championship.
- Results indicated that effective problem-focused coping and viewing situations as challenges helped mediate the positive effects of self-confidence and mental toughness on overall athlete wellbeing and performance, supporting the ideas behind MuSt theory.
Article Synopsis
- Glypican-3 (GPC3) is a potential target for T-cell therapy in hepatocellular carcinoma (HCC), but current CAR T-cell approaches face issues like low persistence and GPC3 shedding.
- Researchers immunized HLA-A2 transgenic mice to find GPC3-specific T-cell receptors (TCRs) and engineered human T cells (TCR-Ts) that effectively recognize GPC3-positive HCC cells.
- TCR-B-T cells showed superior effectiveness compared to traditional CAR T-cells, and combining CAR-T and TCR-B-T cells may enhance therapeutic results in treating HCC.