Publications by authors named "M Adgent"
Article Synopsis
- Prenatal exposure to ozone (O) might influence child lung function, particularly through oxidative stress, and diet may play a role in modifying these effects.
- In a study of 661 women in the CANDLE cohort, no significant associations were found between prenatal O exposure and lung function; however, there were hints of adverse effects during specific fetal development periods.
- Interactions between maternal diet (OBS) and race did not consistently modify the effects of O, although some associations were noted among specific racial groups under certain dietary conditions.
Background: Given the high prevalence of both mental health and acute pain conditions during pregnancy, use of antidepressants and analgesic opioids in this period is widespread. Whether single and combined use of these medications is associated with spontaneous preterm birth (sPTB) remains unclear.
Objectives: To investigate the association between maternal prescription opioid and antidepressant medication exposures for co-occurring mental health and acute pain management, either alone or in combination, and sPTB.
Article Synopsis
- Background research highlights that prenatal exposure to ambient fine particulate matter (PM) may negatively affect child lung health, yet studies specifically investigating the timing of exposure during critical lung development phases are limited.
- The study involved 675 children, tracking prenatal PM exposure and assessing lung function at ages 8-9 through spirometry while controlling for various factors like maternal and child characteristics.
- Results showed weak associations between PM exposure during specific fetal development phases and lung function measures (FEV1 and FVC), with no significant effect from factors like child sex or allergic sensitization.
The FDA Sentinel Real World Evidence Data Enterprise (RWE-DE).
Pharmacoepidemiol Drug Saf
October 2024
Article Synopsis
- - The FDA's Sentinel Innovation Center created a quality-checked network using electronic health records (EHRs) and insurance claims data from over 10 million individuals to enhance regulatory decision-making with real-world data.
- - The resulting network, called the Real-World Evidence Data Enterprise (RWE-DE), includes data from two commercial sources covering 21 million lives and four academic partners covering 4.5 million lives.
- - The report details data completeness, patient populations, and a process for managing free-text notes, while also highlighting potential use cases for RWE-DE to address broader questions in healthcare regulation.
Association of prenatal vitamin E levels with child asthma and wheeze.
Pediatr Allergy Immunol
August 2024
Background: We investigated the individual and interaction effects of maternal plasma 𝛂- and ϒ-tocopherol levels (vitamin E isomers) on child asthma and wheeze at age 8-9.
Methods: Mother-child dyads were enrolled between 2006 and 2011 into the Conditions Affecting Neurocognitive Development and Learning in Early Childhood (CANDLE) prenatal cohort. Maternal second-trimester samples were analyzed for tocopherol and lipid concentrations.