Publications by authors named "M Acuna"
Activation of thermogenic brown adipose tissue (BAT) and inducible beige adipose tissue (BeAT) is triggered by environmental or metabolic stimuli, including cold ambient temperatures and nutrient stress. Thioesterase superfamily member 1 (Them1), a long-chain fatty acyl-CoA thioesterase that is enriched in BAT, suppresses acute cold-induced thermogenesis. Here, we demonstrate that expression was induced in BAT and BeAT by the carbohydrate response element binding protein (ChREBP) in response to chronic cold exposure or to the activation of the integrated stress response (ISR) by nutrient excess.
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- Despite clinical guidelines recommending lower use of central venous catheters (CVC), the prevalence remains high among patients undergoing hemodialysis, leading researchers to explore whether this is due to unavoidable circumstances or factors that can be addressed.
- A study involving 637 chronic hemodialysis patients from various centers in Spain sought to identify modifiable factors influencing CVC use, comparing demographics, vascular access types, and reasons patients had for not using arteriovenous fistulas (AVF).
- Results showed that 40% of the patients utilized CVCs, with major reasons for CVC use including patient refusal for surgery (often due to fear) and having initiated hemodialysis with a CVC, indicating that
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- - The study examines the relationship between tree maturation size and reproduction, finding that larger tree species tend to start reproducing at a smaller size than expected, challenging previous assumptions.
- - Researchers analyzed seed production data from 486 tree species across different climates, revealing that maturation size increases with maximum size but not in a straightforward manner.
- - The results indicate that this trend is particularly pronounced in colder climates, highlighting the importance of understanding maturation size to better predict how forests will respond to climate change and disturbances.
GABAergic neurons and GABA receptors (GABARs) are critical elements of almost all neuronal circuits. Most GABARs of the CNS are heteropentameric ion channels composed of two α, two β, and one γ subunits. These receptors serve as important drug targets for benzodiazepine (BDZ) site agonists, which potentiate the action of GABA at GABARs.
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