Publications by authors named "M Acosta-Zaldivar"
Human lactoferrin (hLf) is an innate host defense protein that inhibits microbial H-ATPases. This protein includes an ancestral structural motif (i.e.
View Article and Find Full Text PDFPhosphorus is essential in all cells' structural, metabolic and regulatory functions. For fungal cells that import inorganic phosphate (Pi) up a steep concentration gradient, surface Pi transporters are critical capacitators of growth. Fungi must deploy Pi transporters that enable optimal Pi uptake in pH and Pi concentration ranges prevalent in their environments.
View Article and Find Full Text PDFPhosphorus is essential in all cells' structural, metabolic and regulatory functions. For fungal cells that import inorganic phosphate (Pi) up a steep concentration gradient, surface Pi transporters are critical capacitators of growth. Fungi must deploy Pi transporters that enable optimal Pi uptake in pH and Pi concentration ranges prevalent in their environments.
View Article and Find Full Text PDFis the most commonly isolated species from patients suffering from invasive fungal disease. is most commonly a commensal organism colonizing a variety of niches in the human host. The fungus must compete for resources with the host flora to acquire essential nutrients such as phosphate.
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- The Target of Rapamycin Complex 1 (TORC1) decides whether eukaryotic cells should focus on growth or survival based on environmental conditions; its dysfunction is lethal to cells.
- The study investigated the role of specific N-terminal HEAT repeats in the Tor1 protein of Candida albicans, discovering that their absence led to significant impairments in stress responses and growth, especially under unfavorable conditions.
- Cells lacking these HEAT repeats showed slow oxygen consumption and were unable to efficiently use non-fermentable carbon sources, leading to sensitivity to respiratory chain inhibitors and deficiencies in cell wall polysaccharides.