Publications by authors named "M Accardo"
Immunotherapy in thymic epithelial tumors: tissue predictive biomarkers for immune checkpoint inhibitors.
Explor Target Antitumor Ther
May 2024
Thymic epithelial tumors (TETs) are rare malignant neoplasms arising in the thymus gland. Nevertheless, TETs, including thymomas (TMs), thymic carcinomas (TCs), and thymic neuroendocrine neoplasms (TNENs), are the most common mediastinal malignancies overall. A multidisciplinary approach is required for the appropriate diagnostic and therapeutic management of TETs.
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- Birt-Hogg-Dubé (BHD) syndrome is a genetic disorder linked to the FLCN gene, causing benign skin lesions, spontaneous lung issues, and an increased risk of kidney tumors.
- A study at the University of Michigan reviewed cases of patients with skin lesions (trichodiscoma and fibrofolliculoma) to evaluate genetics referrals and test results related to BHD.
- Of the 64 patients studied, only 25% were referred for genetic counseling, but among those tested, 64% were diagnosed with BHD, highlighting the importance of early referral for better management of associated conditions.
Idiopathic Interstitial Pneumonias (IIPs) are a heterogeneous group of the broader category of Interstitial Lung Diseases (ILDs), pathologically characterized by the distortion of lung parenchyma by interstitial inflammation and/or fibrosis. The American Thoracic Society (ATS)/European Respiratory Society (ERS) international multidisciplinary consensus classification of the IIPs was published in 2002 and then updated in 2013, with the authors emphasizing the need for a multidisciplinary approach to the diagnosis of IIPs. The histological evaluation of IIPs is challenging, and different types of IIPs are classically associated with specific histopathological patterns.
View Article and Find Full Text PDFA solitary peripheral lung nodule was found in the left lung of a 52-year-old man. It was located in the lower lobe and measured 18.5 cm of major axis on chest computed tomography.
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- A study explored the prevalence of hereditary factors in renal cell carcinoma (RCC) by analyzing the presence of pathogenic or likely pathogenic (P/LP) germline variants in patients who underwent genetic testing.
- Out of 321 analyzed patients, 13.1% had P/LP variants, with notable mutations found in specific genes, and nearly half of these patients had mutations that could be targeted for treatment.
- The research found that bilateral or multifocal tumors were linked to P/LP variants, but factors like age and family cancer history did not significantly affect genetic testing outcomes, emphasizing the need for better genetic evaluation methods in RCC patients.