Publications by authors named "M Abi Daoud Francisco"
Distinguishing tumor maintenance genes from initiation, progression, and passenger genes is critical for developing effective therapies. We employed a functional genomic approach using the Lazy Piggy transposon to identify tumor maintenance genes in vivo and applied this to sonic hedgehog (SHH) medulloblastoma (MB). Combining Lazy Piggy screening in mice and transcriptomic profiling of human MB, we identified the voltage-gated potassium channel KCNB2 as a candidate maintenance driver.
View Article and Find Full Text PDFBackground: Endoscopic retrograde cholangiopancreatography (ERCP) is the first-line procedure for choledocholithiasis treatment. However, it is associated with a 10 % rate of adverse events. Spontaneous migration of common bile duct (CBD) stones occurs in 6-33 % of choledocholithiasis cases, making ERCP avoidable.
View Article and Find Full Text PDFArticle Synopsis
- - Type 2 diabetes mellitus (T2DM) significantly impacts the quality of life for many Filipinos, with genetic factors contributing to 30-70% of the disease risk.
- - This study examined the genetic variants linked to T2DM among Filipinos by comparing 66 individuals with diabetes to 121 without, identifying nine significant genetic variants tied to glucose and energy metabolism.
- - Key variants, particularly CDKAL1 (rs7766070), show the highest risk levels, suggesting their potential use as markers for early detection and prevention of T2DM in the Filipino population.