Risk of Incident Cancer in Veterans with Diabetes Who Use Metformin Versus Sulfonylureas.

Prior research suggests metformin has anti-cancer effects, yet data are limited. We examined the association between diabetes treatment (metformin versus sulfonylurea) and risk of incident diabetes-related and non- diabetes-related cancers in US veterans. This retrospective cohort study included US veterans, without cancer, aged ≥ 55 years, who were new users of metformin or sulfonylureas for diabetes between 2001 to 2012.

Antimicrobial Stewardship Intervention for the Family Caregiver Attending Primary Health Care Setting: A Quasi-Experimental Study.

Antimicrobial resistance (AMR) has been identified as one of the top ten public health threats facing humanity. The purpose of this study was to assess the effect of an antimicrobial stewardship educational intervention on family caregivers' knowledge and practices in primary healthcare settings in Egypt. A quasi-experimental, one-group pretest-posttest design involving a sample of 300 family caregivers attending family health centers.

Evaluation of Anti-Angiogenic Therapy Combined with Immunotherapy and Chemotherapy as a Strategy to Treat Locally Advanced and Metastatic Non-Small-Cell Lung Cancer.

Immunotherapy has made recent improvements in disease-free survival (DFS) and/or overall survival (OS) in all stages of non-small-cell lung cancer (NSCLC). Here, we review the tumor microenvironment and its immunosuppressive effects and discuss how anti-angiogenic therapies may potentiate the anti-carcinogenic effects of immunotherapy. We also review all the past literature and discuss strategies of combining anti-angiogenic therapy and immunotherapy +/- chemotherapy and hypothesize how we can use this strategy for non-small-cell lung cancer in metastatic previously untreated/previously treated settings in previously treated EGFR-mutated NSCLC for the upfront treatment of brain metastases prior to radiation therapy and for the incorporation of this strategy into stage III unresectable disease.

Sex-based differences in cardiovascular outcomes among patients with atrial fibrillation undergoing left atrial appendage occlusion device placement.

Background: There is a growing body of data to support the presence of sex disparities in outcomes of cardiovascular related hospitalizations. Despite this, there remains a paucity of data on relationships between sex and in-hospital outcomes in patients receiving a left atrial appendage occlusion device (LAAOD).

Methods: We examined the 2016-2020 Nationwide Readmission Database to identify patients with Atrial Fibrillation receiving a LAAOD.

Distribution and risk assessment of phenols and polycyclic aromatic hydrocarbons in sediments from the continental shelf adjacent to Nile River estuaries, Egypt.

Background: The highly industrialized areas characterize the delta coasts of the world, due to the discharging of large quantity of wastewater into the river estuaries. The entrance of phenolic compounds and PAHs into the aquatic environment has not been sufficiently studied on the Egyptian Mediterranean coast. The article examines the content and ecological risks associated with 11 phenolic compounds and 14 PAHs in the bottom sediments of the Nile River estuaries, the largest river systems that discharged into the Mediterranean Sea.