Predictive role of [F]FDG PET-CT radiomic parameters for KRAS/BRAF/EGFR mutations in metastatic colorectal cancer patients.

Objectives: The objective of this study was to evaluate the predictive value of F-fluorodeoxyglucose [F]FDG positron emission tomography (PET-CT) radiomic parameters in relation to KRAS/BRAF/EGFR mutations in patients with metastatic colorectal cancer (mCRC).

Methods: Blood samples were collected from 90 mCRC patients to assess KRAS G13V, BRAF V600E, and EGFR exon 20 mutations. [F]FDG PET-CT scans were performed, and radiomic parameters, including the SUV max, max TBR, total MTV, and total TLG, were calculated and correlated with different genotypes and haplotypes of the aforementioned mutations.

Radiographers' knowledge, clinical expertise and application of pain management strategies in the radiology department - results from a qualitative focus group.

Background: Radiographers are frequently involved in imaging patients in pain thus requiring a heightened awareness and focus on this crucial issue.

Purpose: To explore the challenges radiographers encounter when imaging patients in pain and to identify strategies that could be implemented to improve overall patient-centered care.

Methods: A qualitative research study with a single focus group (FG) was conducted using six radiographers working within Irish hospitals.

Functional genomics of primary congenital glaucoma by pathway analysis and functional characterization of CYP1B1 mutations.

CYP1B1 is the most common gene implicated in primary congenital glaucoma (PCG) - the most common form of childhood glaucoma. How CYP1B1 mutations cause PCG is not known. Understanding the mechanism of PCG caused by CYP1B1 mutations is crucial for disease management, therapeutics development, and potential prevention.

Cartilaginous Choristoma of the Oral Cavity: A Rare Presentation in the Nasopharynx.

This case report describes a rare presentation of a cartilaginous choristoma of the oral cavity within the tonsillar fossa, emphasizing the importance of recognizing and differentiating this uncommon entity from more frequently encountered oral lesions. A comprehensive clinical and histopathological examination was conducted on a 30-year-old male patient who presented with a painless mass in the nasopharynx. An excisional biopsy was carried out, and a histopathological analysis was conducted to establish a definitive diagnosis.

Expression of concern: Optimized Cu-doping in ZnO electro-spun nanofibers for enhanced photovoltaic performance in perovskite solar cells and photocatalytic dye degradation.

Expression of concern for 'Optimized Cu-doping in ZnO electro-spun nanofibers for enhanced photovoltaic performance in perovskite solar cells and photocatalytic dye degradation' by Kang Hoon Lee , , 2024, , 15391-15407, https://doi.org/10.1039/D4RA01544D.