Publications by authors named "M ARAI"
Article Synopsis
- ECPR has enabled previously ineligible patients with refractory out-of-hospital cardiac arrest (OHCA) from acute myocardial infarction (AMI) to undergo primary percutaneous coronary intervention (PCI).
- A study examined 671 patients over five years, finding that 37% of them had refractory cardiac arrest despite ECPR, with about 65% achieving return of spontaneous circulation (ROSC) post-PCI and 21% surviving to discharge.
- Key factors influencing survival included having prehospital ROSC, quicker ECPR initiation, and achieving a high TIMI flow grade after the procedure.
Most actinomycetes and fungi have a multitude of silent biosynthetic genes whose activation could lead to the production of new natural products. Our group recently designed and used a co-culture method to isolate new natural products, based on the idea that pathogens might produce immune suppressors to avoid attack by immune cells. Here, we searched for compounds produced by the co-culture of immune cells with pathogenic fungi isolated from clinical specimens.
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- In April 2020, new guidelines by the Japanese Circulation Society recommended shorter dual antiplatelet therapy (DAPT) for high bleeding risk patients, prompting a study in June 2020 involving 1,136 patients who had undergone percutaneous coronary intervention (PCI).
- The study found that 55.2% of patients received planned short DAPT (less than 3 months), resulting in a significantly shorter average DAPT duration compared to those on standard therapy, but similar rates of major adverse cardiovascular events and bleeding complications across both groups.
- Key factors predicting adverse events included age 75 or older, certain health conditions like severe chronic kidney disease, and low hemoglobin levels, indicating that despite the shorter therapy,
Background/aim: Few studies have examined the association between programmed cell death ligand 1 (PD-L1) expression in small cell lung cancer and the effect of chemoimmunotherapy.
Patients And Methods: Patients diagnosed with extensive-stage small cell lung cancer at our hospital between September 2019 and August 2023, who were treated with atezolizumab plus carboplatin and etoposide and had pathological tissue immunostained with SP142, were retrospectively examined to determine whether treatment efficacy differed depending on the expression of PD-L1.
Results: Twenty-nine patients were analyzed.
Regeneration of periodontal tissue, particularly the cementum-periodontal ligament (PDL)-bone complex, has long been challenging because the differentiation kinetics of cells and the molecular pathways contributing to the regeneration process are largely unknown. We aimed to evaluate the cell behavior and molecular pathways that contribute to periodontal tissue regeneration in vivo. We analyzed the process of periodontal tissue regeneration through subrenal capsule transplantation of immediately extracted molars in mice.
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