Publications by authors named "M ADLOFF"
Article Synopsis
- The East Antarctic Ice Sheet's expansion during the Eocene-Oligocene Transition represents a significant shift in Earth's climate, driven by lower atmospheric CO2 and changes in Earth's orbit.
- The study reveals evidence of a major regression on continental shelves, highlighting increased delivery of organic matter to the oceans, coinciding with deep ocean carbonate dissolution and phytoplankton extinction.
- Utilizing an Earth System model, the research suggests that this surge of organic carbon may have temporarily counteracted climate cooling effects from the glacial expansion.
The biological carbon pump (BCP) stores ∼1,700 Pg C from the atmosphere in the ocean interior, but the magnitude and direction of future changes in carbon sequestration by the BCP are uncertain. We quantify global trends in export production, sinking organic carbon fluxes, and sequestered carbon in the latest Coupled Model Intercomparison Project Phase 6 (CMIP6) future projections, finding a consistent 19 to 48 Pg C increase in carbon sequestration over the 21st century for the SSP3-7.0 scenario, equivalent to 5 to 17% of the total increase of carbon in the ocean by 2100.
View Article and Find Full Text PDFRandomized trial of 5-fluorouracil, leucovorin and cisplatin in advanced pancreatic cancer.
Hepatogastroenterology
January 2002
Background/aims: Phase II trials of combined 5 fluorouracil, leucovorin and cisplatin have demonstrated an 18-28% response rate in advanced pancreatic carcinomas. We investigated the effect of this chemotherapy regime on patients' survival.
Methodology: Patients included gave informed consent.
Objective: To review the features of adult patients undergoing surgery for bile duct cysts, focusing on the anatomy of the biliary tree as well as the long-term outcome.
Summary Background Data: Bile duct cysts (BDCs) are uncommon in Western countries, and the majority of reported cases originate from Asia. Japanese authors have emphasized the frequent association of extra- and intrahepatic bile duct dilatations, but grading of patients based on Todani's classification is often hindered by the absence of an accurate definition of types IC and IVA cysts.
Assessment of biliary excretion of piperacillin-tazobactam in humans.
Antimicrob Agents Chemother
August 1997
Piperacillin-tazobactam concentrations in serum and bile were measured intraoperatively in 10 patients undergoing cholecystectomy (group 1) and 5 cholecystectomized patients provided with external bile duct drainage (group 2). Each patient received a single intravenous dose of piperacillin at 4 g plus tazobactam at 0.5 g over 30 min.
View Article and Find Full Text PDF