Publications by authors named "M ABRAHAMSON"
This study introduces novel cospray-dried (Co-SD) formulations of simvastatin, a Nrf2 activator ROCK inhibitor, with l-carnitine as molecular mixtures in various molar ratios for targeted pulmonary inhalation aerosol delivery in pulmonary hypertension, optimized for excipient-free dry powder inhalers (DPIs). The two components were spray-dried at various molar ratios by using different starting feed solution concentrations and process parameters. In addition to comprehensive physicochemical characterization, in vitro aerosol dispersion performance as DPIs using two FDA-approved DPI devices with different shear stress properties, in vitro viability as a function of dose on 2D human pulmonary cellular monolayers and on 3D small airway epithelia human primary cultures at the air-liquid interface (ALI), and in vitro transepithelial electrical resistance (TEER) at the ALI were conducted.
View Article and Find Full Text PDFObjective: To assess self-reported awareness of diabetic retinopathy (DR) and concordance of eye examination follow-up compared with findings from concurrent retinal images.
Research Design And Methods: We conducted a prospective observational 10-year study of 26,876 consecutive patients with diabetes who underwent retinal imaging during an endocrinology visit. Awareness and concordance were evaluated using questionnaires and retinal imaging.
Article Synopsis
- Chronic kidney disease of non-traditional origin (CKDnt) and acute kidney injury (AKI) are common among heat-stressed manual workers in Mesoamerica, particularly during sugarcane harvests.
- A study compared inflammation-related proteins in sugarcane cutters who experienced increases in serum creatinine levels (cases) to those with stable levels (controls) to understand the role of inflammation in kidney injury.
- Results showed an elevation of certain inflammation-related proteins in cases before and during harvest, suggesting a link between inflammation and kidney injury that could contribute to conditions like CKDnt.
Article Synopsis
- Doctors often check kidney function using two markers: creatinine and cystatin C.
- In 2010, using both markers together helped discover new kidney problems called selective glomerular hypofiltration syndromes, which are serious and can increase the risk of illness and death.
- The current guidelines don’t recommend cystatin C as a main marker, so many patients with these kidney issues might not be identified; experts believe cystatin C should be included in future guidelines.
Objective measures of balance and gait have the potential to improve prediction of future fallers because balance and gait impairments are common precursors. We used the Instrumented Stand and Walk Test (ISAW) with wearable, inertial sensors to maximize the domains of balance and gait evaluated in a short test. We hypothesized that ISAW objective measures across a variety of gait and balance domains would improve fall prediction beyond history of falls and better than gait speed or dual-task cost on gait-speed.
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