Adjunctive treatments for pneumococcal meningitis: a systematic review of experimental animal models.

New treatments are needed to improve the prognosis of pneumococcal meningitis. We performed a systematic review on adjunctive treatments in animal models of pneumococcal meningitis in order to identify treatments with the most potential to progress to clinical trials. Studies testing therapy adjunctive to antibiotics in animal models of pneumococcal meningitis were included.

Stakeholders' perceptions and preferences towards industrial water sensitive development in New Zealand.

Understanding stakeholders' perceptions and preferences is key to promoting Industrial Water Sensitive Design (IWSD). A questionnaire was distributed to stakeholders in a conventional New Zealand industrial area. The results showed that technological feasibility limitation, institutional inertia, and cognitive shortage were the main barriers to IWSD application, though stakeholders supported IWSD and preferred the vegetation-based measures.

Clinical features and prognostic factors in Covid-19: A prospective cohort study.

Background: Mortality rates are high among hospitalized patients with COVID-19, especially in those intubated on the ICU. Insight in pathways associated with unfavourable outcome may lead to new treatment strategies.

Methods: We performed a prospective cohort study of patients with COVID-19 admitted to general ward or ICU who underwent serial blood sampling.

Demonstrating the need to simultaneously implement all water sensitive design methods for aquatic ecosystem health.

The practices commonly known as 'Water Sensitive Design', or 'Low Impact Urban Design and Development', provide a comprehensive package of practices, (building blocks), that respect and work with the natural water cycle and enhance biodiversity. Much previous research has focussed on determining the sustainability gains achieved by the implementation of a narrow range of closely related techniques, such as the installation of at-source devices for stormwater retention and treatment. Other research has investigated the gains for the health of an ecosystem from the reduction of impervious surfaces, or from riparian revegetation, or from the clustering together of buildings.

Effect of exercise and/or reduced calorie dietary interventions on breast cancer-related endogenous sex hormones in healthy postmenopausal women.

Background: Physical inactivity and being overweight are modifiable lifestyle risk factors that consistently have been associated with a higher risk of postmenopausal breast cancer in observational studies. One biologic hypothesis underlying this relationship may be via endogenous sex hormone levels. It is unclear if changes in dietary intake, physical activity, or both, are most effective in changing these hormone levels.