Evolutionary Pressures Shape Undifferentiated Pleomorphic Sarcoma Development and Radiotherapy Response.

Radiotherapy is an integral component in the treatment of many types of cancer, with approximately half of cancer patients receiving radiotherapy. Systemic therapy applies pressure that can select for resistant tumor subpopulations, underscoring the importance of understanding how radiation impacts tumor evolution to improve treatment outcomes. We integrated temporal genomic profiling of 120 spatially distinct tumor regions from 20 patients with undifferentiated pleomorphic sarcomas (UPS), longitudinal circulating tumor DNA (ctDNA) analysis, and evolutionary biology computational pipelines to study UPS evolution during tumorigenesis and in response to radiotherapy.

Kidney graft directly implanted on endovascular stent in external iliac artery; a preliminary experience.

With an increasingly aging population, both end-stage renal disease and peripheral artery disease become more prevalent. Peripheral artery disease is increasingly treated with endovascular procedures. Endovascular stenting of the external iliac artery (EIA) is often considered a contraindication for kidney transplantation, as clamping of the artery could result in possible injuring of the stent.

The impact of wearing compression hosiery and the use of assistive products for donning and doffing: A descriptive qualitative study into user experiences.

This qualitative study aimed to describe users' experiences and needs related to wearing, donning, and doffing compression hosiery, and the provision process of compression hosiery and associated assistive products for donning and doffing. Adults who have been advised to wear compression hosiery participated in semi-structured interviews. Existing frameworks about the provision process and acceptance of assistive technology guided the topic list.

Venous Stents Placed for Postthrombotic Syndrome: The Role of Inflow Disease on Patency.

Purpose: To identify the risk of deep femoral vein (DFV) and/or femoral vein (FV) inflow disease on venous stent patency loss in postthrombotic syndrome (PTS).

Materials And Methods: This single-center retrospective study included limbs with iliofemoral and iliocaval stents for PTS. Single-vessel and double-vessel inflow disease were defined on the basis of imaging of possible postthrombotic changes in the DFV/FV.