Publications by authors named "M A Yorek"
Article Synopsis
- High levels of tumor-associated macrophages (TAMs) in breast cancer are linked to worse outcomes for patients, with lipid buildup in these cells driving tumor growth and spread.
- Recent research reveals that unsaturated fatty acids (like linoleic acid) are more effective than saturated fats at creating lipid droplets in macrophages, using the FABP4/CEBPα pathway to promote this process.
- FABP4 not only aids in lipid metabolism in TAMs but also enhances fat breakdown and utilization in breast cancer cells, fostering cell migration and metastasis, highlighting its critical role in cancer progression.
SCN8A developmental and epileptic encephalopathy (DEE) is a severe epilepsy syndrome resulting from mutations in the voltage-gated sodium channel Nav1.6, encoded by the gene SCN8A. Nav1.
View Article and Find Full Text PDFUnlabelled: A high density of tumor-associated macrophages (TAMs) is associated with poorer prognosis and survival in breast cancer patients. Recent studies have shown that lipid accumulation in TAMs can promote tumor growth and metastasis in various models. However, the specific molecular mechanisms that drive lipid accumulation and tumor progression in TAMs remain largely unknown.
View Article and Find Full Text PDFCombination therapy is it in the future for successfully treating peripheral diabetic neuropathy?
Front Endocrinol (Lausanne)
May 2024
In 2022, the Center for Disease Control and Prevention reported that 11.3% of the United States population, 37.3 million people, had diabetes and 38% of the population had prediabetes.
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