Extracellular Regucalcin: A Potent Suppressor in the Cancer Cell Microenvironment.

The regucalcin gene is located on the X chromosome, comprising seven exons and six introns. This gene and protein are expressed in various tissues and cells and is predominantly expressed in human liver, kidney, and adrenal tissues. Regucalcin gene expression is enhanced via a mechanism mediated by several signaling molecules and transcription factors.

Efficacy and safety of avacopan in antineutrophil cytoplasmic autoantibody-associated vasculitis: a retrospective cohort study in Japan.

Background: Avacopan, an oral C5a receptor antagonist, demonstrated efficacy as an alternative to glucocorticoid therapy in patients with antineutrophil cytoplasmic antibody (ANCA)-associated vasculitis (AAV) in the phase 3 ADVOCATE trial. However, limited real-world data exist on the outcomes and experiences associated with avacopan use for AAV in Japan.

Methods: We performed a single-centre retrospective analysis and evaluated 21 patients with newly diagnosed or relapsed AAV who received avacopan.

Recyclable and air-stable colloidal manganese nanoparticles catalyzed hydrosilylation of alkenes with tertiary silane.

We synthesized ,-dimethylformamide (DMF)-stabilized manganese nanoparticles (Mn NPs) in a one-step process under air using manganese(ii) chloride as the precursor. The Mn NPs were characterized in terms of particle size, oxidation state, and local structure using annular dark-field scanning transmission electron microscopy (ADF-STEM), X-ray photoelectron spectroscopy (XPS), and X-ray absorption spectroscopy (XAS). The results indicate that Mn NPs are divalent nanosized particles with Mn-O bonds.

Anti-inflammatory effect of Angiotensin 1-7 in white adipose tissue.

Obesity is a global health concern that promotes chronic low-grade inflammation, leading to insulin resistance, a key factor in many metabolic diseases. Angiotensin 1-7 (Ang 1-7), a component of the renin-angiotensin system (RAS), exhibits anti-inflammatory effects in obesity and related disorders, though its mechanisms remain unclear. In this study, we examined the effect of Ang 1-7 on inflammation of white adipose tissue (WAT) in dietary-induced obese mice.