Computed tomography morphomics and antifibrotic therapy in idiopathic pulmonary fibrosis.

Aim: Idiopathic pulmonary fibrosis (IPF) is a debilitating and fatal lung disease. Changes in body composition potentially correlate with outcomes in patients with IPF.

Materials And Methods: Patients with IPF on antifibrotic treatment attending a single institution were identified and retrospectively evaluated (n=84).

An investigation into the relationships between technical collision behaviours and physical characteristics in world-class, international female rugby players.

This study first investigated how the probability of winning collision events is affected by technical characteristics among world-class, international female rugby union players, and second, whether enhanced performance of these technical characteristics was related to physical attributes. Carry and tackle events from 16 international matches played by a top-two world ranking team were coded according to technical characteristics and performance outcomes. Binary classification tree models revealed that carry performance was successfully predicted ( < 0.

Determination of the optimal dose and dosing strategy for effective L-menthol oral rinsing during exercise in hot environments.

Purpose: This multi-study programme investigated the optimal concentration of L-menthol delivered as an oral mouth rinse to modulate thermo-behaviour during exercise in a hot environment (35 °C).

Method: In study 1, 38 participants completed a survey to establish an effective and tolerable range of L-menthol concentration. 31 participants completed an RPE-protocol examining 1.

Inflammatory markers in early knee joint osteoarthritis differ from well-matched controls and are associated with consistent, rather than intermittent knee pain.

Background: Osteoarthritis (OA) is characterised by the failure of normal biological processes to repair following damage. Traditionally, OA was considered a "wear and tear" disorder; however, it is now a recognised inflammatory condition, preceded by molecular modifications. The aim of this study was to evaluate inflammatory markers among individuals with early knee OA (eKOA) and well-matched asymptomatic controls.

The effects of exercise, heat-induced hypo-hydration and rehydration on blood-brain-barrier permeability, corticospinal and peripheral excitability.

Purpose: The effects of low-intensity exercise, heat-induced hypo-hydration and rehydration on maximal strength and the underlying neurophysiological mechanisms are not well understood.

Methods: To assess this, 12 participants took part in a randomised crossover study, in a prolonged (3 h) submaximal (60 W) cycling protocol under 3 conditions: (i) in 45 °C (achieving ~ 5% body mass reduction), with post-exercise rehydration in 2 h (RHY2), (ii) with rehydration across 24 h (RHY24), and (iii) a euhydrated trial in 25 °C (CON). Dependent variables included maximal voluntary contractions (MVC), maximum motor unit potential (M), motor evoked potential (MEP) amplitude and cortical silent period (cSP) duration.