[Basal-luminal epithelial cell differentiation in prostate cancer is associated with epithelial-mesenchymal transition and epithelium migration in the mesenchyme].

Aim: In patients with prostate cancer to trace the pathway of the malignant cells of the basal layer of the prostate epithelium during their differentiation into luminal cells and/or migration in the mesenchyme.

Materials And Methods: We used histological and immunohistochemical staining of the markers of the basal layer of the prostate: cytokeratin 5 (CK5), E-cadherin and AMACR, and Western blot to assess the production of the same markers in epithelial and stromal compartments of malignant and normal prostate tissue in patients with prostate cancer.

Results: Our findings revealed that prostate cancer is associated with losing of the basal epithelial layer in the prostate tumor tissue, which is accompanied by a complete loss of CK5 secretion, increased levels of E-cadherin and AMACR in luminal epithelium and the emergence of cells producing E-cadherin and AMACR in the stromal compartment of the prostate.

[Short-term results of radical cystectomy].

The paper presents the results of 114 radical cystectomies made in 1996-2002. The age of 114 patients (103 males, 11 females) ranged from 37 to 78 years (mean age 57.5 years).

[The psychological reasons for the varying efficacy of suggestion in an experiment].

In 86 neurotic patients, judgements about TAT pictures were defined before a session of hypnosis. Later other judgments about the same pictures were suggested after the patients entered the hypnotic state. 34 patients who were in a deep enough hypnotic state manifested the lack of suggestion realization, which can be accounted for by image and intellectual activity that occurred at the moment of suggestion.

[Method of studying psychotherapeutic resistance during the conduct of hypnotic sessions for neurotic patients].

The available methods of determination of hypnosis liability are restricted to investigation of the possibility of suggestion of motor acts, various sensations, etc., and cannot provide an answer as to suggestibility with regard to the patient's ability to change his or her opinions under the effect of direct therapeutic hypnosis. In this connection the author proposes an experimental-psychological method of determining this suggest ability with the help of TAT pictures.