Evaluating Resonant Acoustic Mixing as a Wet Granulation Process.

Control of powder properties is crucial for industrial processes across the food, pharmaceutical, agriculture, and mineral processing industries, and granulation is an important tool for providing agglomerated particles with controllable properties. However, existing granulation processes are not readily integrated with other processing steps and are not appropriate for some types of materials. Adding resonant acoustic-based granulation to the toolkit has the potential to widen the achievable parameter space and, importantly, integrate granulation into chemistry and blending operations that are already being performed on the RAM platform, resulting in process intensification.

[Neutrophil-to-lymphocyte ratio as a predictor of intestinal resection in incarcerated inguinal hernias].

Introduction: Inguinal hernia is defined as a projection of an organ through the inguinal canal. This can be incarcerated as a consequence of continuous inflammation of the hernial sac, which will prevent its return, causing damage to the venous and lymphatic return of the viscera. The neutrophil-to-lymphocyte ratio (NLR) is an easily accessible inflammatory biomarker obtained from blood cell counts.

DAPTEV: Deep aptamer evolutionary modelling for COVID-19 drug design.

Typical drug discovery and development processes are costly, time consuming and often biased by expert opinion. Aptamers are short, single-stranded oligonucleotides (RNA/DNA) that bind to target proteins and other types of biomolecules. Compared with small-molecule drugs, aptamers can bind to their targets with high affinity (binding strength) and specificity (uniquely interacting with the target only).

Hybrid 2D-CMOS microchips for memristive applications.

Exploiting the excellent electronic properties of two-dimensional (2D) materials to fabricate advanced electronic circuits is a major goal for the semiconductor industry. However, most studies in this field have been limited to the fabrication and characterization of isolated large (more than 1 µm) devices on unfunctional SiO-Si substrates. Some studies have integrated monolayer graphene on silicon microchips as a large-area (more than 500 µm) interconnection and as a channel of large transistors (roughly 16.