SARS-CoV-2 spike peptide analysis reveals a highly conserved region that elicits potentially pathogenic autoantibodies: implications to pan-coronavirus vaccine development.

The SARS-CoV-2 pandemic, while subsiding, continues to plague the world as new variants emerge. Millions have died, and millions more battle with the debilitating symptoms of a clinical entity known as long Covid. The biggest challenge remains combating an ever-changing variant landscape that threatens immune evasion from vaccine and prior infection-generated immunity.

Neuroepidemiology of transverse myelitis and its etiologies in Latin America: A systematic review and meta-analysis.

Background And Objectives: Transverse myelitis (TM) is a rare neuro-inflammatory condition of the spinal cord that can cause chronic and debilitating symptoms reducing quality of life. TM is understudied in developing regions worldwide, particularly in Latin America and the Caribbean (LAC), where the prevalence of TM is unknown. Etiologies of TM are variable, but certain infectious, autoimmune or nutritional abnormalities may be more common in LAC with differing estimated prevalences of these etiologies.

Adapting the NIMHD Research Framework for Type 2 Diabetes-Related Disparities.

Purpose Of Review: Type 2 diabetes (T2D) disproportionately impacts minority populations. The National Institute on Minority Health and Health Disparities (NIMHD) developed a research framework to encourage health disparities research that considers a multi-level, multi-domain perspective. The purpose of this review was to describe evidence on the levels and domains that influence T2D disparities among minority populations and use this information to adapt the NIMHD Research Framework for T2D.

Surrogate Simulation of Subject-Specific Lateral Pinch via Deep Learning.

Musculoskeletal modeling and simulation is often a lengthy and computationally expensive process, particularly when developing and using personalized models. We present a deep learning-based adaptive surrogate model for lateral pinch, which accepts both musculoskeletal parameters and muscle activations as input for personalization and simulation. This model matches traditional OpenSim forward dynamics with an average root-mean-squared error (RMSE) of 2.