Publications by authors named "M A Vadyukhin"
Article Synopsis
- Kidney disease is becoming a major global health concern, with projections indicating it will rank as the fifth-leading cause of life lost by 2040.
- The research focuses on understanding the dose-dependent effects of electron irradiation on renal tissue, as the impact of this type of radiation is not well studied compared to others like gamma and X-rays.
- Findings show that higher doses of electron irradiation cause increased oxidative stress, inflammation, and significant damage to kidney tissue, including apoptosis and early fibrosis, highlighting the importance of managing radiation doses to protect kidney function.
Article Synopsis
- Radiotherapy can lead to premature ovarian failure and infertility in cancer patients, highlighting the need for ovarian radioprotection methods.
- Electron irradiation is a promising but under-researched option that has less toxic effects on surrounding tissues compared to other radiation types.
- The study shows that leukocyte-poor platelet-rich plasma can mitigate the negative effects of electron irradiation on ovarian function by promoting healing and reducing inflammation through specific cellular mechanisms.
Background: Research on the subject of the influence of SARS-CoV-2 mechanisms on human homeostasis remains an actual problem. Particular interest is the study of pathomorphological changes in the appendix in children with COVID-19.
Objectives: Aim of this study: morphological and molecular biological evaluation of the appendix in children of different age groups with COVID-19.
Background: Skin cancer is the most frequently diagnosed type of cancer among all malignant neoplasms. The decrease in mitotic activity and the death of intact keratinocytes arise due to the constantly renewing epithelium being highly sensitive to ionizing radiation.
Aim: The aim of the study is immunohistochemical evaluation of the proliferative-apoptotic balance of keratinocytes, the fibrous component of the skin, and the expression of pro-inflammatory and anti-inflammatory cytokines after single or fractional local electron irradiation.
Background: At present, the damage of male reproductive function caused by electron irradiation, as well as the development of methods for its correction are the relevant topics for further research. In fact, the effect of leukocyte-poor platelet-rich plasma (LP-PRP) growth factors are poorly investigated on different aspects of male fertility.
Methods: In this study, Wistar rats were divided into four groups; I) control which were injected with saline; II and III) groups (n=65) whose testes were locally irradiated with electrons to a dose of 2 Gy (linear accelerator "NOVAC-11"); III) the group (n=30) which received LP-PRP for 11 weeks after irradiation; and IV) animals (n=30) which received only LP-PRP (conditional control).