Melatonin mitigates nickel oxide nanoparticles induced phytotoxicity in soybean by reducing metal accumulation, enhancing antioxidant defense and promoting nitrogen assimilation.

Heavy metals like nickel (Ni) from anthropogenic activities damage plant growth, posing challenges to agriculture. Melatonin (ME), a potent bio-regulator, has shown promise in alleviating stress induced by heavy metals. However, the mechanisms through which ME alleviates NiO-NPs phytotoxicity remain unclear.

Increasing Incidence of Coronary Artery Disease in Younger Men: Case Study of a 39-Year-Old.

Coronary artery disease (CAD) is the leading cause of death globally. While it is usually diagnosed after years of declining health or after a myocardial infarction (MI), we found that patients can be asymptomatic, posing a latent and life-threatening risk. We present the case of a man less than 40 years old, in whom heart disease was incidentally discovered during a CT scan performed for an unrelated condition.

Clinical whole Exome Sequencing Reveals Novel Homozygous Missense Variant in the Gene causing Autosomal Recessive Spinocerebellar Ataxia.

Background & Objective: Autosomal recessive cerebellar ataxias (ARCA) are rare heterogenous neurodegenerative disorders characterized by degeneration of the cerebellum and spinal cord with an early onset before the age of 20 years. PMPCA (MIM: 613036), is a key enzyme in mitochondrial protein processing which is critical for cell survival and growth. Our objective was to investigate Peptidase, Mitochondrial Processing Subunit Alpha (PMPCA) mutations linked with Spinocerebellar ataxia, autosomal recessive 2 (SCAR2).