Fluorescence emission from tryptophan residues has been often used to probe the protein structure due to its transition dipole moment sensitivity to the local environment. We report the fluorescence study of a collagen-like peptide heterotrimer modified with the tryptophan in the X position (X-Y-Gly) that shows the diminished fluorescence in a homotrimer versus a heterotrimer when the L state is selectively excited. This behavior is only observed in folded peptides, below the helix-to-coil transition temperature, and can be explained by long-range interactions between the tryptophans located on different strands within the triple helix, not by the change in the local environment.
View Article and Find Full Text PDFEnvironmental mercury (Hg) contamination of the global tropics outpaces our understanding of its consequences for biodiversity. Knowledge gaps of pollution exposure could obscure conservation threats in the Neotropics: a region that supports over half of the world's species, but faces ongoing land-use change and Hg emission via artisanal and small-scale gold mining (ASGM). Due to their global distribution and sensitivity to pollution, birds provide a valuable opportunity as bioindicators to assess how accelerating Hg emissions impact an ecosystem's ability to support biodiversity, and ultimately, global health.
View Article and Find Full Text PDFFemale urethral adenocarcinoma (FUA) is extremely rare. It is an aggressive malignancy, and clear cell and columnar/mucinous ("intestinal") represent the two primary histologic subtypes. Diagnosis is often delayed in patients because of their vague symptomatology; hence, they present with an advanced disease and a poor prognosis.
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