[The use of immunoglobulins and monoclonal antibodies against COVID-19].

Introduction: When a new disease occurs, one of the most affordable remedies is drugs containing specific antibodies to this infectious agent. The use of such drugs is aimed at reducing the amount of the pathogen in the macroorganism and the associated reduction in the severity of the symptoms of the disease or recovery. The purpose of this review is to analyze the experience of using immunoglobulins and monoclonal antibodies in the treatment of COVID-19 patients during the pandemic.

Ecotoxicity of polyelectrolyte formulations in water and soil matrices.

Interpolyelectrolyte complexes (IPECs) formed by the interaction of two oppositely charged polyelectrolytes have been proposed as soil structure stabilizers. However, little is known about the environmental safety of IPECs. The goal of this study was to investigate the toxicity of a positively charged IPEC formed by two commercial polymers, namely the cationic biopolymer poly(diallyldimethylammonium chloride) (PDDA) and the anionic biopolymer lignohumate (LH), a humic-based plant growth promoter.

[Prevention of periprocedural kidney ingury by loading doses of statins in elective percutaneous сoronary interventions].

Purpose Of The Study: To compare the effect of loading doses of atorvastatin and rosuvastatin on the value of the acute kidney injury and acute inflammatory response to elective percutaneous coronary interventions.

Materials And Methods: An open prospective comparative study included 68 patients referred for elective percutaneous coronary intervention (PCI). At baseline, all patients had been taking statins for a long time as a standard lipid-lowering therapy.

Lower Urinary Tract Symptoms in Metabolic Syndrome in Young Adults.

Background And Objective: Metabolic syndrome (MS) is widespread among middle age people and presents an acute issue in preventive cardiology. A list of conditions associated with MS is quite long and it is constantly growing. Despite the data, described in scientific literature, on general pathogenetic mechanisms, the conditions associated with androgynous status, are not included into the register of MS associated nosologies.

Particular Role of JAK/STAT3 Signaling in Functional Control of Mesenchymal Progenitor Cells.

The role of JAK/STAT3-mediated signaling pathway in the realization of the growth potential of mesenchymal precursor cells was examined in vitro. The stimulating role of JAKs and STAT3 towards proliferating activity of progenitor cells and their different role in the regulation of differentiation of the progenitor elements were demonstrated. Inhibitors of JAKs and STAT3 reduced the yield of fibroblast CFU and their mitotic activity.