Publications by authors named "M A Tedesco"

Introduction: This study aimed to evaluate the angular kinematics of the hip, knee, ankle, and the linear kinematics of the barbell during the back squat (BS) at different load intensities in powerlifters and weightlifters.

Methods: Seventeen athletes were recruited ( = 14 powerlifters;  = 3 weightlifters). The 1-RM of the BS of each participant was calculated and, 1-week after, each participant was asked to perform 5 trials of the BS at different load intensities (i.

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Research about health and environmental impacts of pollution caused by natural and plastic fibres is increasing, however, the role of textile characteristics in microfibre release during washing remains poorly understood. Given that machine washing is thought to be the main contributor to microfibre pollution, we systematically and critically reviewed previous publications looking at how textile features affect fibre emissions during washing. We examined the evidence related to findings from previous studies based on their research aims, ability to control variables that could confound results, use of procedural blanks and controls, and statistical methodologies.

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The human brain is a complex organ with an intricate neuronal connectivity and diverse functional regions. Neurological disorders often disrupt the delicate balance among these anatomical compartments, resulting in severe impairments. The available therapeutic options constitute an incomplete solution as many patients respond partially, highlighting the need for continued research into causes and treatments.

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Article Synopsis
  • PDIA3 is an important protein in the endoplasmic reticulum that plays a key role in protein folding and is linked to diseases like cancer and neurodegeneration.
  • Punicalagin is a promising but non-selective PDIA3 inhibitor, prompting the exploration of its derivative, punicalin, which has a simpler structure and better selectivity towards PDIA3.
  • Studies show that punicalin effectively binds and inhibits PDIA3, demonstrating higher selectivity compared to PDIA1, and causes significant changes in PDIA3's thermal stability, highlighting its potential for developing selective PDIA3 inhibitors.
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