Publications by authors named "M A Stillman"
Article Synopsis
- Oxidative stress contributes to various diseases, including neurodegenerative conditions like Alzheimer's, where reactive oxygen species (ROS) disrupt protein function.
- Metallothionein-3 (MT3), a metalloprotein abundant in the brain, is shown to play a crucial role in managing oxidative stress, especially when it binds with metals like zinc or cadmium.
- The study presents findings that indicate MT3 oxidizes more rapidly than its kidney counterpart (MT1), with distinct oxidation pathways that suggest a protective role for zinc in its fully metalated form.
Background: Despite studies demonstrating that patients with peritoneal metastases from low-grade appendiceal adenocarcinoma (AA) do not respond well to systemic chemotherapy (SC), patients frequently undergo combination of SC with cytoreductive surgery/hyperthermic intraperitoneal chemotherapy (CRS/HIPEC) regardless of grade.
Methods: A nationwide retrospective analysis using the National Cancer Database evaluated patients with AA with peritoneal metastasis from 2016 to 2021. Cox proportional hazards model was used to evaluate the impact of SC in addition to CRS/HIPEC on overall survival (OS) stratified by tumor grade.
Objectives: We previously described a 6-item teamwork index (TEAM) with a strong relationship to provider experience, lower burnout, and intent to stay. We now sought to determine whether (1) TEAM relates to higher patient Net Promoter Score (NPS, or likelihood of patient referring to the organization) and (2) teamwork mediates a provider experience-NPS relationship.
Study Design: A provider wellness survey was administered in the fall of 2019 in 6 care delivery organizations (CDOs) with patient NPS data.
Purpose: Renal transplantation and end-stage renal disease are increasingly common. Renal dysfunction and immunosuppression are two risk factors in the development of renal cell carcinoma. Carcinomas in these patients are thought to be more indolent, however data are limited and mixed.
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