Publications by authors named "M A Spano"
The aim of this study was to evaluate the metabolomic profile of larvae reared on the following innovative growth substrates: wheat bran (control, CTRL); wheat bran supplemented with 12.5% / chestnut shell (TRT1); and wheat bran supplemented with 25% / chestnut shell (TRT2) for 14 days of trial. At the end of this experiment, larvae were transformed into insect meals for nutritional characterization.
View Article and Find Full Text PDFNeurodegenerative diseases are among the major challenges in modern medicine, due to the progressive aging of the world population. Among these, Parkinson's disease (PD) affects 10 million people worldwide and is associated with the aggregation of the presynaptic protein α-synuclein (α-syn). Here we use two different PD models, yeast cells and neuroblastoma cells overexpressing α-syn, to investigate the protective effect of an extract from the cocoa shell, which is a by-product of the roasting process of cocoa beans.
View Article and Find Full Text PDFArticle Synopsis
- Nearly half of the global population is affected by an infection, with current treatments involving antibiotics and proton pump inhibitors; however, rising antimicrobial resistance remains a major issue.
- Phenolic monoterpenes like eugenol, vanillin, carvacrol, and thymol are of interest for their biological activities and potential for easy modifications, leading to the creation of mono- and bis-azo derivatives through aryl diazotization.
- The synthesized compounds were tested against various bacterial strains, revealing some effective inhibitors and subsequently underwent cytotoxicity evaluations and target investigations using structure-based docking calculations on key pharmacological targets.
New Insights Into TRMT10A Syndrome: Case Report and Literature Review.
Am J Med Genet B Neuropsychiatr Genet
October 2024
Article Synopsis
- * A patient was found with a specific mutation in TRMT10A causing issues like spastic-ataxic paraparesis and a variant of Dandy-Walker malformation.
- * This case suggests that TRMT10A may play a critical role in brain development, indicating a need for further research into its effects on neurological conditions and potential treatments.