Publications by authors named "M A Solinas"
Modelling delay discounting behavior in rodents is important for understanding the neurobiological mechanisms underlying cognitive control and associated impulsivity disorders. Conventional rodent delay discounting procedures require extensive training and frequent experimenter interaction, as rodents are tested in separate operant chambers away from their home cage. To address these limitations, we adapted and characterize here a self-adjusting delay discounting procedure to an automated CombiCage setup.
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- Pancreatic ductal adenocarcinoma (PDAC) is difficult to diagnose early due to vague symptoms and a lack of biomarkers, and the study aims to explore the role of microRNAs (miRNAs) in PDAC progression and cancer stem cells (CSCs).
- Researchers analyzed miRNA profiles from PDAC patient samples and cell lines to identify specific miRNAs associated with the disease and examined their expression in CSC models.
- The study identified a panel of 9 PDAC-associated miRNAs, showing significant dysregulation particularly in CSC models, with notable overexpression of miR-4486, miR-216a-5p, and miR-216b-5p in cancer stem cells compared to
An important body of literature suggests that exerting intense cognitive effort causes mental fatigue and can lead to unhealthy behaviors such as indulging in high-calorie food and taking drugs. Whereas this effect has been mostly explained in terms of weakening cognitive control, cognitive effort may also bias behavioral choices by amplifying the hedonic and emotional impact of rewards. We report parallel findings with animals and humans supporting this hypothesis.
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- This study compared the outcomes of two aortic valve replacement methods—sutureless aortic valve replacement (SUAVR) and transcatheter aortic valve implantation (TAVI)—in patients with small aortic annulus (SAA).
- A total of 622 patients were analyzed, and after matching for key characteristics, 146 patients from each group were evaluated for all-cause death at 36 months and other complications.
- Results indicated that the TAVI group had a higher rate of all-cause death (21% vs. 12.2%) and more major adverse cardiovascular and cerebrovascular events (32.6% vs. 18.1%), while both methods showed similar hemodynamic performances.