[Catalase gene polymorphism is associated with increased risk of cerebral stroke in hypertensive patients].

Experimental and clinical studies suggest that oxidative stress is an important pathogenetic mechanism of both essential hypertension (EH) and cerebral stroke (CS). In this paper, we investigated, for the first time, the relationship between polymorphisms of two genes for antioxidant defense enzymes such as catalase (CAT) and flavin-containing monooxygenase 3 (FMO3) and the risk of CS in hypertensive patients. DNA samples obtained from 667 unrelated Russian patients with EH (306 patients with CS, and 361 patients without cerebrovascular accidents) were genotyped for polymorphisms -21A>T (rs7943316) of the CAT gene and E158K (rs2266782) of the FMO3 gene.