Publications by authors named "M A Sobol'"

Recently, there has been an increase in the number of aid campaigns launched via social media. The paper explores the phenomenon called "helping by clicking," which consists in clicking "Like" to support a charitable campaign or cause. The main aim of the paper is to present a new measure: The Helping by Clicking Types Questionnaire (HCTQ), assessing the patterns of helping by clicking.

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Introduction: The main goals of septorhinoplasty are to correct cosmetic and functional defects, which may occur in a patient with no history of previous trauma. As the most prominent facial feature, the nose has an increased risk of injury. Nasal fracture may eventually result in significant defects; posing challenges to the surgeon.

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Article Synopsis
  • - MICAL proteins are essential for controlling actin filaments in cells, affecting important processes such as cell shape, division, and nerve growth, but their activity needs careful regulation to avoid harmful changes in cell structure.
  • - Previous research hinted that MICAL proteins are kept inactive (autoinhibited) and need specific proteins (Rab proteins) to activate, but the exact details weren't clear until now.
  • - The study unveils the structure of MICAL1, revealing how its activation relies on internal interactions within the protein and connections with other protein domains, highlighting a similar mechanism across different MICAL proteins.
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Clinical genetic laboratories often require a comprehensive analysis of chromosomal rearrangements/structural variants (SVs), from large events like translocations and inversions to supernumerary ring/marker chromosomes and small deletions or duplications. Understanding the complexity of these events and their clinical consequences requires pinpointing breakpoint junctions and resolving the derivative chromosome structure. This task often surpasses the capabilities of short-read sequencing technologies.

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Drug-induced differential gene expression analysis (DGEA) is essential for uncovering the molecular basis of cell phenotypic changes and understanding individual tumor responses to anticancer drugs. Performing high throughput DGEA is challenging due to the high cost and labor-intensive multi-step sample preparation protocols. In particular, performing drug-induced DGEA on cancer cells derived from patient biopsies is even more challenging due to the scarcity of available cells.

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