[Oxazole derivatives as compounds modifying radiation effects in the body of mice].

A new class of substances exhibiting radioprotective and radiosensitizing effects depending on the concentration of the substance has been found. The radioprotective effect is probably due to the resonant absorption of radiation energy and its transformation into low-energy forms, as well as reactions with water radiolysis products. We studied the effects of 2,5-difeniloxazole and di[2-(5-feniloxazolil)]benzene in various concentrations in conjunction with irradiation on the growth of melanoma B-16 in mice and the average time of their lives.

[The creation of tests for the estimation of the biological consequences of X-ray radiation at low doses and changing dose rate on animals].

The dependence of "biological effect-dose" in experiments on mature outbreed mice (females) is studied during 30 days after low intensity X-ray action at the total dose less than 1 mGy. The index (relative mass) of the murine spleen was decreased in the group of mice which have the low value of the spleen index in the control. It is shown that the value of these parameters in groups of irradiated mice is mainly due to the total X-ray doses.

[Changes in the lipid peroxidation systems in tissues from various rodent species during aging].

The comparative investigation of parameters of the physicochemical regulatory system of the lipid peroxidation (LPO) in liver, spleen and blood components of laboratory rodents of 5 strains and species was carried out. The interrelation between the LPO intensity and the cell-free DNA content in the blood plasma of mice has been shown. The absence of the same type and direct changes of the LPO regulatory system parameters during aging was shown.

[Modifying properties of 2,5-diphenyloxazole during low-dose X-ray exposure of mice].

The ability of 2,5-diphenyloxazole (DPO) to modify biological consequences of the X-rays irradiation of mice was studied with a dose of 16 cGy at the administration of the agent in a wide range of concentrations before or after irradiation was studied. It was shown that the administration of the agent in doses 9.9 x 10(-3)-9.

[The dynamics of physiological and biochemical indices of mouse status as a function of concentration of chemical toxicants in drinking water extracts].

The effect of single per os administration of oil solution of hexane-ether extracts with different contents of benzo[a]pyrene and polychlorobiphenyls on the dynamics of physiological and biochemical indices in the liver and blood of mice proved to significantly depend on chemical composition and concentration of the extract as well as time period after administration. No linear effect-dose relationships have been revealed for both physiological and biochemical indices. Administration of low doses of the extracts changed the scale and the degree of the relationship between mouse body weight and liver weight.