Publications by authors named "M A Simonian"
Mitochondrial activity directs neuronal differentiation dynamics during brain development. In this context, the long-established metabolic coupling of mitochondria and the eukaryotic host falls short of a satisfactory mechanistic explanation, hinting at an undisclosed facet of mitochondrial function. Here, we reveal an RNA-based inter-organellar communication mode that complements metabolic coupling of host-mitochondria and underpins neuronal differentiation.
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- This pilot study evaluates the quality of genomics and proteomics data from both FFPE and frozen tissue biopsies of LIRADS 5 hepatocellular carcinoma (HCC).
- The preliminary results indicated that fresh frozen samples showed better efficacy in identifying differentially expressed proteins and genes in varying histological grades of HCC.
- The findings provide important insights for selecting appropriate samples for future research on HCC.
Background: WWTR1 or TAZ is a transcriptional co-activator protein expressed in cytoplasm which functions as the main downstream effector of the Hippo signaling pathway. This pathway is an evolutionally conserved signal cascade, which plays a pivotal role in organ size control and tumorigenesis. Ectopic expression of TAZ has already been observed in many malignancies, while the ectopic localization of TAZ is reported for the first time.
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- Triple-negative breast cancer (TNBC) is a tough type of cancer, and researchers are looking for new ways to treat it using special molecules.
- They found that a molecule called Fibromodulin (FMOD) is on the surface of some cancer cells, which could help target TNBC with new treatments.
- Tests showed that a special drug made with FMOD can kill TNBC cells and slow down tumors in mice, suggesting it might be a good way to treat this type of cancer in the future.
Monoclonal Antibody Against Sortilin Induces Apoptosis in Human Breast Cancer Cells.
Avicenna J Med Biotechnol
January 2022
Background: Sortilin has an important role in various malignances and can be used as a promising target to eradicate cancer cells.
Methods: In this study, the expression of sortilin in 4T1 and MDA-MB231 cell lines was evaluated by flow cytometry and immunocytochemistry. Apoptosis assay was also applied to evaluate apoptosis induction in 4T1 and MDA-MB231 cell lines.