Publications by authors named "M A Shoulkamy"
Ionizing radiation induces various types of DNA damage, and the reparability and lethal effects of DNA damage differ depending on its spatial density. Elucidating the structure of radiation-induced clustered DNA damage and its repair processes will enhance our understanding of the lethal impact of ionizing radiation and advance progress toward precise therapeutics. Previously, we developed a method to directly visualize DNA damage using atomic force microscopy (AFM) and classified clustered DNA damage into simple base damage clusters (BDCs), complex BDCs and complex double-strand breaks (DSBs).
View Article and Find Full Text PDFMetabolic abnormalities play a pivotal role in various pathological conditions, necessitating the quantification of specific metabolites for diagnosis. While mass spectrometry remains the primary method for metabolite measurement, its limited throughput underscores the need for biosensors capable of rapid detection. Previously, we reported that pillar[6]arene with 12 carboxylate groups (P6AC) forms host-guest complexes with 1-methylnicotinamide (1-MNA), which is produced in vivo by nicotinamide -methyltransferase (NNMT).
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- Differentiation therapy shows potential for treating acute myeloid leukemia (AML), but effective methods that work across different AML subtypes are needed.
- The study reveals that inhibiting a specific regulatory element of FOXO genes can induce differentiation in AML cells, identifying TRIB1 as a key gene that keeps these cells undifferentiated.
- A new therapeutic approach combining a DNA-binding inhibitor with a chemotherapy drug effectively reduced TRIB1 levels, leading to AML cell differentiation and inhibiting tumor growth in animal models without significant side effects.
RHEB is a potential therapeutic target in T cell acute lymphoblastic leukemia.
Biochem Biophys Res Commun
September 2022
Article Synopsis
- T cell acute lymphoblastic leukemia (T-ALL) is a severe type of cancer involving immature T cells, and current treatments often fail, leading to relapses and poor outcomes.
- Researchers identified RHEB, a key regulator of the mTOR signaling pathway, as a promising target for therapy in T-ALL.
- The study showed that disabling RHEB in T-ALL cells caused cell death by disrupting nucleotide production, and this approach also reduced tumor growth in animal models, suggesting a potential effective treatment strategy.
Envenomation and death resulting from snakebites represent a significant public health problem worldwide, particularly in tropical and subtropical regions. The WHO has defined snakebite as a neglected tropical health concern. Bites from Macrovipera lebetina obtusa usually cause life-threatening systemic hemodynamic disturbances, reduced functionality of the kidneys, and other serious symptoms, including hypotension shock, edema, and tissue necrosis, at the bite site.
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