[The role of plant compounds in the prevention of oncologic diseases].

The paper presents summarized data on numerous biologically active compounds found in plants. Their anticancer preventive potential is analyzed as well as possibility of their use to stimulate anticancer resistance of the body. Antimutagenic, anticarcinogenic, immunomodulating and other characteristics of organic and inorganic compounds of plant origin are considered in detail.

[Development of substances for active prevention of cancer based on vitamins and preventive-treatment products].

The conception and program are described for development of drugs involved in active prophylaxis of malignant neoplasms. Development of prophylactic drugs and new treatment-prophylactic food-stuffs was shown to be possible and expedient to use toxic immunomodulators and natural anticarcinogens. Complex drugs are assumed to include carotenoids, tocopherols, water-soluble vitamins, polysaccharides and other biologically active substances exhibiting anticarcinogenic, antimutagenic and immunostimulating properties.

[Antimutagenic properties of substances containing beta-carotene].

Two carotene-containing drugs (natural and artificial) were shown to decrease the rate of chromosomal aberrations, induced by cyclophosphane, in bone marrow cells of mice, daily ration of which contained 10-20 mg/kg of beta-carotene within 1-3 weeks. The rate of chromosomal aberrations induced was decreased 1.5-2-fold in various experiments.

[Relation between DNA replication and neutral Mn 2+-dependent DNAse activity in chromatin].

In cultures of primary murine fibroblasts the 10% serum stimulates the replicative synthesis of DNA inhibited by aphidicolin and araC (cytosine arabinoside). Using direct immunofluorescence analysis, it was shown that antibodies penetrate inside the cells and after 4 hours are pooled in the nuclei, where they remain for another 20 hours. The substitution of antibodies against chromatin DNAase by bovine serum albumin of normal serum gamma-globulins does not interfere with the DNA synthesis induction.