Publications by authors named "M A Sharpe"
Article Synopsis
- * The review aimed to evaluate discharge opioid prescribing practices for neurosurgical patients and assess whether neurosurgeons are over-prescribing opioids, as existing literature on this topic is limited.
- * A systematic review identified 23 relevant studies, revealing a mix of over-prescribing and under-prescribing of opioids, highlighting a need for individualized patient care and better quality research to help establish effective prescribing guidelines.
Humans and non-humans alike often make choices to gain information, even when the information cannot be used to change the outcome. Prior research has shown the anterior cingulate cortex (ACC) is important for evaluating options involving reward-predictive information. Here we studied the role of ACC in information choices using optical inhibition to evaluate the contribution of this region during specific epochs of decision making.
View Article and Find Full Text PDFBackground: Glioblastoma (GBM) uses Glut3 and/or Glut14 and the Leloir pathway to catabolize D-Galactose (Gal). UDP-4-deoxy-4-fluorogalactose (UDP-4DFG) is a potent inhibitor of the two key enzymes, UDP-galactose-4-epimerase (GALE) and UDP-Glucose 6-dehydrogenase (UGDH), involved in Gal metabolism and in glycan synthesis. The Gal antimetabolite 4-deoxy-4-fluorogalactose (4DFG) is a good substrate for Glut3/Glut14 and acts as a potent glioma chemotherapeutic.
View Article and Find Full Text PDFArticle Synopsis
- Maladaptive decision-making is common in substance use disorders (SUDs), but the effects of drugs on brain processes related to decision-making are not fully understood.
- Past research typically focused on individual neuron activity, but this study emphasizes the need to analyze groups of neurons (ensembles) for a clearer picture.
- The findings reveal that cocaine use weakened and changed the brain's representations of important information for decision-making, potentially leading to poor choices, providing insights that could improve future treatment approaches for SUDs.