Publications by authors named "M A Sharaf"
Objectives: To prospectively evaluate the effect of guselkumab through 48 weeks across various clinical outcomes in subgroups of patients with psoriatic arthritis (PsA) and inadequate response to tumour necrosis factor inhibitors (TNFi-IR) from the phase 3b COSMOS trial. Subgroups were defined by baseline demographics, disease characteristics and prior/ongoing therapies.
Methods: Patients with active PsA (tender joint count (TJC) and swollen joint count (SJC) both ≥3) and TNFi-IR were randomised 2:1 to receive guselkumab 100 mg at week 0, week 4, then every 8 weeks through week 44 or to placebo with cross-over to guselkumab 100 mg at week 16 (early escape) or week 24 (planned).
Background: Unless a health intervention is acceptable to target audience and aligns with their needs and preferences, there is increased likelihood that they would not engage with and benefit from it as planned. Despite that, there is paucity of studies exploring acceptability of oral health promotion interventions prior to implementation. This cross-sectional study was designed to investigate Egyptian women's " to use mobile technologies in promoting access to oral health services.
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- The study aimed to better understand severe serine biosynthesis defects by examining prenatal and postnatal effects in 12 unrelated Egyptian families with suspected Neu-Laxova syndrome (NLS).
- Researchers employed fetal ultrasound, postnatal assessments, and whole exome sequencing (WES) to analyze this new cohort and reviewed existing literature for a broader context.
- Findings included novel clinical signs and the identification of several genetic variants, expanding the understanding of serine biosynthesis disorders and highlighting the importance of prenatal exome sequencing.
Article Synopsis
- - Kidney failure leads to the build-up of harmful substances, known as uremic toxins, in the blood, which can increase the risk of serious health issues in patients.
- - Standard hemodialysis is often ineffective at clearing certain uremic toxins due to their strong binding to serum albumin, prompting researchers to explore advanced technologies like iron oxide magnetic nanoparticles for improved removal.
- - Studies indicated that albumin-modified nanoparticles had better hemocompatibility and reduced clotting compared to unmodified ones, suggesting they may be more effective for safely clearing uremic toxins from the blood.
Hydrogen and renewable fuels were generated using cost-effective and efficient electrocatalysts for water splitting. In this work, a CuO-based photocathode is used for the water splitting to generate hydrogen energy by PVD technique. The XRD analysis reveals the deposition of CuO thin film on ITO substrates, which is monoclinic.
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