Publications by authors named "M A Senchenko"
Undifferentiated pleomorphic sarcoma (UPS) is a highly malignant mesenchymal tumor that ranks as one of the most common types of soft tissue sarcoma. Even though chemotherapy increases the 5-year survival rate in UPS, high tumor heterogeneity frequently leads to chemotherapy resistance and consequently to recurrences. In this study, we characterized the cell composition and the transcriptional profile of UPS with resistance to chemotherapy at the single cell resolution.
View Article and Find Full Text PDFPurpose: Nodular lymphocyte-predominant Hodgkin lymphoma (NLPHL) is a rare cancer, and large international cooperative efforts are needed to evaluate the significance of clinical risk factors and immunoarchitectural patterns (IAPs) for all stages of pediatric and adult patients with NLPHL.
Methods: Thirty-eight institutions participated in the Global nLPHL One Working Group retrospective study of NLPHL cases from 1992 to 2021. We measured progression-free survival (PFS), overall survival (OS), transformation rate, and lymphoma-specific death rate.
Background: Nodular lymphocyte predominant Hodgkin lymphoma (NLPHL) consist of lymphocyte predominant cell or LP-cell. Despite their origin from active germinal centers, in some cases LP-cells express IgD, which is characteristic of naive B-lymphocytes of the mantle zone. Due to the rarity of NLPHL, assessing the frequency of IgD-positive cases is difficult.
View Article and Find Full Text PDFMelanotic neuroectodermal tumor of infancy. Clinical case of large fontanel tumor and literature review.
Zh Vopr Neirokhir Im N N Burdenko
December 2022
Article Synopsis
- Melanotic neuroectodermal tumor of infancy (MNTI) is a type of tumor common in newborns, known for its rapid growth and tendency to come back after treatment.
- In this case, a 6-month-old boy had surgery to remove the tumor located on his skull, but it recurred just 3 weeks later, leading to a second surgery and radiation therapy.
- After 6 months of follow-up, there was no tumor growth, but overall, the best treatment approach for MNTI remains uncertain based on limited information.