Current Analytical Methods and Challenges for the Clinical Diagnosis of Invasive Pulmonary Aspergillosis Infection.

In the last decade, pulmonary fungal infections such as invasive pulmonary aspergillosis (IPA) have increased in incidence due to the increased number of immunocompromised individuals. This increase is especially problematic when considering mortality rates associated with IPA are upwards of 70%. This high mortality rate is due to, in part, the length of time it takes to diagnose a patient with IPA.

Laboratory Studies on the Influence of Hydrogen on Titan-like Photochemistry.

Laboratory investigations of photochemical reactions in simulated Titan-like atmospheric systems provide insight into the formation of gas and aerosol products and the influence of different environmental parameters on the types of organic molecules generated. Studying the gas-phase products as a function of reaction time provides further insight into the reaction pathways that lead to organic production. The stable isotopes in the reactants and products serve as tracers and help to disentangle these reaction pathways.

Human neural stem cells directly programmed from peripheral blood show functional integration into the adult mouse brain.

Transplantation of induced pluripotent stem cell-derived neural cells represents a promising strategy for treating neurodegenerative diseases. However, reprogramming of somatic cells and their subsequent neural differentiation is complex and time-consuming, thereby impeding autologous applications. Recently, direct transcription factor-based conversion of blood cells into induced neural stem cells (iNSCs) has emerged as a potential alternative.