Evaluation of the Degradation Properties of Plasma Electrolytically Oxidized Mg Alloy AZ31 Using Fluid Dynamic Accelerated Tests for Biodegradable Implants.

Magnesium alloys are promising biodegradable implant materials due to their excellent biocompatibility and non-toxicity. However, their poor corrosion resistance limits their application in vivo. Plasma electrolytic oxidation (PEO) is a powerful technique to improve the corrosion resistance of magnesium alloys.

Beyond Fundamental Building Blocks: Plasticity in Structurally Complex Crystals.

Intermetallics, which encompass a wide range of compounds, often exhibit similar or closely related crystal structures, resulting in various intermetallic systems with structurally derivative phases. This study examines the hypothesis that deformation behavior can be transferred from fundamental building blocks to structurally related phases using the binary samarium-cobalt system. SmCo and SmCo are investigated as fundamental building blocks and compared them to the structurally related SmCo and SmCo phases.

Rehabilitation after surgical release of the stiff elbow: A literature review.

Background: Elbow stiffness poses a significant challenge for surgeons as well as physiotherapists during and after surgery. To date, there is no consensus regarding the subsequent rehabilitation after surgical release of the stiff elbow.

Objective: The aim is to evaluate the most important therapeutic strategies following open or arthroscopic release of the stiff elbow based on a comprehensive literature review, and to develop a consensus for or against specific therapeutic methods with the help of a survey among elbow experts of the D-A-CH Association for Shoulder and Elbow Surgery (DVSE).

Tonabersat enhances temozolomide-mediated cytotoxicity in glioblastoma by disrupting intercellular connectivity through connexin 43 inhibition.

Glioblastoma cells rely on connexin 43 (Cx43)-based gap junctions (GJs) for intercellular communication, enabling them to integrate into a widely branched malignant network. Although there are promising prospects for new targeted therapies, the lack of clinically feasible GJ inhibitors has impeded their adoption in clinical practice. In the present study, we investigated tonabersat (TO), a blood-brain-barrier-penetrating drug with GJ-inhibitory properties, in regard to its potential to disassemble intercellular connectivity in glioblastoma networks.

Epitranscriptomic rRNA fingerprinting reveals tissue-of-origin and tumor-specific signatures.

Mammalian ribosomal RNA (rRNA) molecules are highly abundant RNAs, decorated with over 220 rRNA modifications. Previous works have shown that some rRNA modification types can be dynamically regulated; however, how and when the mammalian rRNA modification landscape is remodeled remains largely unexplored. Here, we employ direct RNA sequencing to chart the human and mouse rRNA epitranscriptome across tissues, developmental stages, cell types, and disease.