Subjective Patient Rating as a Novel Feedback Signal for DBS Programming in Parkinson's Disease.

Background: Deep brain stimulation of the subthalamic nucleus (STN-DBS) effectively alleviates motor fluctuations in Parkinson's disease (PD). Optimal electrode placement and effective programming significantly influence outcomes. From a patient's perspective, DBS should relieve motor symptoms while avoiding side effects.

Clinical heterogeneity and treatment outcomes of extrapulmonary tuberculosis in a low-incidence setting: insights from a prospective cohort study.

Purpose: Tuberculosis (TB) remains a leading cause of morbidity and mortality, with 1.3 million deaths in 2022. Extrapulmonary tuberculosis (EPTB) accounts for approximately 20% of all TB cases.

Clonal Hematopoiesis Landscape in Frequent Blood Donors.

Donor blood saves lives, yet the potential impact of recurrent large-volume phlebotomy on donor health and hematopoietic stem cells (HSCs) remains largely unexplored. In our study, we conducted a comprehensive screening of 217 older male volunteer donors with a history of extensive blood donation (>100 life-time donations) to investigate the phenomenon of clonal hematopoiesis (CH). No significant difference in the overall incidence of CH was found in frequent donors (FD) compared to sporadic donors (<10 life-time donations, 212 donors).

Association Between Inpatient Medication Treatment for Opioid Use Disorder and Reduced One-Year All-Cause Mortality in Patients With Invasive Bacterial Infections.

Invasive bacterial infections are frequent causes of hospitalization among people who use opioids. We evaluated the association between inpatient administration of medication for opioid use disorder with one-year all-cause mortality in patients hospitalized with invasive bacterial infections.

Reasons for emergency department use of low-acuity attender: results from the prospective, multicentre, cross-sectional EPICS-9/PiNo-Bund study.

Background: The number of low-acuity emergency department (ED) visits varies across Europe and is often posited as a contributing factor to ED crowding. Many health policy-makers and health professionals assume that these cases are 'avoidable' ED visits or could be referred to other ambulatory healthcare providers.

Objectives: This study examines the care-seeking behaviour and the reasoning behind patients with low-acuity ED attendance according to emergency triage.