Publications by authors named "M A Sawant"
Article Synopsis
- Non-healing diabetic foot ulcers (DFUs) pose a risk for amputations, and hyperbaric oxygen therapy (HBOT) is explored as a potential treatment to enhance healing and lower amputation rates, although its effectiveness remains debated.
- A study was conducted with 60 adult patients with DFUs, randomly assigning them to two groups: one receiving HBOT alongside standard wound care (SWC) and the other receiving SWC alone, evaluating various outcomes over four weeks.
- Results indicated that patients receiving HBOT showed significantly greater improvements in pain, wound size, and healthy tissue formation, as well as a lower incidence of minor amputations compared to those with SWC alone.
Article Synopsis
- Antibody variable regions are responsible for binding to specific antigens, but they can also interact non-specifically, affecting the performance of antibody therapeutics in various ways.
- Researchers analyzed over 300,000 antibody sequences to find that the heavy chain mainly determines non-specific interactions due to its properties, such as positive charge and hydrophobicity, which can be assessed using a machine learning model.
- The study identifies key features, particularly those involving tyrosine, that influence both non-specific binding and specific antigen recognition, providing insights for antibody design and understanding molecular immunology.
Introduction One of the most frequent emergencies that a general surgeon deals with is perforation peritonitis. The anatomical site of the perforation, which in turn affects the source of infection, has a major impact on the mortality rate due to perforation peritonitis. Early and suitable antibiotic therapy can be started in the postoperative period with the aid of knowledge about the microbiological profile and sensitivity of peritoneal fluid culture with respect to the anatomical sites of perforation peritonitis.
View Article and Find Full Text PDFUncontrolled secretion of ECM proteins, such as collagen, can lead to excessive scarring and fibrosis and compromise tissue function. Despite the widespread occurrence of fibrotic diseases and scarring, effective therapies are lacking. A promising approach would be to limit the amount of collagen released from hyperactive fibroblasts.
View Article and Find Full Text PDFDeep inspiratory breath-hold radiotherapy on a Helical Tomotherapy unit: Workflow and early outcomes in patients with left-sided breast cancer.
Tech Innov Patient Support Radiat Oncol
June 2024
Article Synopsis
- The study presents a novel approach to deep inspiratory breath-hold (DIBH) radiotherapy for left-sided breast cancer using a specially designed frame and manual gating to minimize cardiac exposure.
- Results showed a significant reduction in cardiac dose with DIBH compared to conventional free-breathing techniques, with heart dose reduced by 34% and various cardiac substructures receiving lower doses.
- The workflow enhances patient safety and treatment precision, with no observed recurrences in patients during a 9-month follow-up period, demonstrating its efficacy in this clinical setting.