Recent advancements in cGAS-STING activation, tumor immune evasion, and therapeutic implications.

The cGAS-STING signaling pathway is indeed a pivotal component of the immune system and serve as a crucial link between innate and adaptive immune responses. STING is involved in the cellular response to pathogen invasion and DNA damage, and which has important consequences for host defense mechanisms and cancer regulation. Ongoing research aiming to modulate the cGAS-STING pathway for improved clinical outcomes in cancer and autoimmune diseases is underway.

Comparison of Atherosclerotic Cardiovascular Disease Risk Scoring Systems in Bangladeshi Population.

Risk stratification is an important initial step for primary prevention of atherosclerotic cardiovascular diseases. There are a number of scoring systems for this purpose worldwide. We tried to evaluate two most updated scoring systems.

Phytochemical Profiling and Antimicrobial Properties of Various Sweet Potato ( L.) Leaves Assessed by RP-HPLC-DAD.

This study aimed to investigate the leaves of six cultivars of L. from the USA, focusing on their Total Polyphenol Content (TPC), Total Flavonoid Content (TFC), antioxidant, and antimicrobial activities. TPC and TFC ranged from 7.

Successful closure of a refractory giant (15 sq mm) macular hole with amniotic membrane graft.

The management of macular hole defects has undergone a significant transformation with the advent of advanced diagnostic tools and surgical techniques. These developments have enabled the effective treatment of macular holes that were previously considered untreatable. Although the majority of patients exhibit a positive response to initial treatment, a subset of patients may develop refractory macular holes that necessitate multiple surgeries for closure.