[The expertise evaluation of organization of rendering of acute, emergency and urgent medical care in rural regions of Novosibirsk oblast'].

The most problematic spheres in the resource support of emergency medical care to rural residents are the completeness of staff of physicians in rural medical surgeries, community hospitals and departments of emergency medical care in central district hospitals. The provision of feldsher obstetrics posts with sanitary motor transport and medical equipment is yet another problematic sphere. The main troubles during provision of emergency medical care at feldsher obstetrics posts are related to surgery treatment.

[Effect of alendronate on bone tissue status of senescence-accelerated OXYS rats].

The purpose of this research was to study the effect of Alendronate on bone mineral density (BMD) and markers of bone turnover in male and female Wistar rats and senescence-accelerated OXYS rats with early development of osteoporosis. The animals were treated with Alendronate (0.84 mg/kg) during 2 months from the age of 8 months.

[Cathepsin K and matrix metalloproteases activity in the bone tissue of OXYS rats with developing osteoporosis].

The comparative study of activity of cysteine protease cathepsin K and matrix metalloproteases (MMPs) in bone tissue of accelerated senescent OXYS rats with early ageing comparatively to Wistar rats of the same age was performed. Early development osteoporosis is a typical feature of OXYS rats. In bone tissue of 3 month old OXYS rats, before appearance of osteoporosis manifestation cathepsin K activity was higher, whereas MMPs activity was lower than in Wistar rats.

[Development of osteoporosis in prematurely aging OXYS rats].

The early osteoporosis in OXYS rats is the presentation of accelerated senescence and earlier positioned as senile. The present study shows the changes in metabolism detected in OXYS rats in the postnatal period. They lead to the development of osteoporosis in future and may underlie the formation of reduced peak bone mass.

[Bone matrix glycosaminoglycans and osteoporosis development in early aging OXYS rats].

Proteoglycans play a crucial role in bone tissue formation promoting consolidation of collagen fibers and bonds between them and mineral crystals. The composition of extracellular matrix proteoglycans was analyzed in early aging OXYS rats with signs of early osteoporosis versus Wistar rats at the age of 2, 4, 6, and 8 months. It was found that bone mineral density in two month OXYS rats was lower than in age-matched Wistar rats.