Publications by authors named "M A Saavedra Melendez"
Study Design: Retrospective cohort.
Objective: To explore the relationship between symptomatic pseudoarthrosis requiring revision after lumbar fusion and antidepressant use.
Summary Of Background Data: Approximately 25% of patients undergoing spine surgery are taking antidepressants.
Optical matter, a transient arrangement formed by the interaction of light with micro/nanoscale objects, provides responsive and highly tunable materials that allow for controlling and manipulating light and/or matter. A combined experimental and theoretical exploration of optical matter is essential to advance our understanding of the phenomenon and potentially design applications. Most studies have focused on nanoparticles composed of a single material (either metallic or dielectric), representing two extreme regimes, one where the gradient force (dielectric) and one where the scattering force (metallic) dominates.
View Article and Find Full Text PDFUnlabelled: Parenteral nutrition (PN) is a life-sustaining method to provide adequate nutrients to patients unable to receive oral or enteral nutrition. PN typically contains a mixture of macro- and micro-nutrients, although the lipid composition has been identified as a concern for liver disease. Therefore, the study of the intravenous lipid emulsion (ILE) prescribing practices in home-based PN (HPN) patients and whether differing lipid PN alters liver function tests (LFTs) is needed.
View Article and Find Full Text PDFDevelopment and evaluation of high-resolution melting assays for direct and simultaneous pathogen identification in bloodstream infections in pediatric oncology patients.
Diagn Microbiol Infect Dis
November 2024
Article Synopsis
- Blood culture is a slow and often ineffective method for identifying pathogens in bloodstream infections, particularly concerning for pediatric oncology patients facing febrile neutropenia.
- Two new High-Resolution Melting (HRM) assays were developed, showing excellent specificity and the ability to detect very low amounts of bacterial DNA, outperforming traditional blood culture methods.
- The HRM assays demonstrated variable sensitivity in identifying pathogens from blood samples of pediatric cancer patients, indicating their potential as a quicker diagnostic tool for managing infections in this vulnerable group.
Germline TP53 pathogenic variants can lead to a cancer susceptibility syndrome known as Li-Fraumeni (LFS). Variants affecting its activity can drive tumorigenesis altering p53 pathways and their identification is crucial for assessing individual risk. This study explored the functional impact of TP53 missense variants on its transcription factor activity.
View Article and Find Full Text PDF